Download Free PDF View PDF
Download Free PDF View PDF
SSRN Electronic Journal
Download Free PDF View PDF
Download Free PDF View PDF
Download Free PDF View PDF
Entrepreneurship Theory & Practice
The case examines the current problems facing Google during one of the worst economic environments since the Great Depression. Google was faced with stagnant net profits and employee turnover, while trying to maintain their culture of corporate entrepreneurship and innovation. The case was written for senior level undergraduate and MBA students in entrepreneurship and business strategy. It can be taught in one hour and twenty minutes. The amount of outside work to prepare for the case is expected to be at least four hours. The case outlines the history of the Silicon Valley titan, Google, Inc., and how it will navigate in one of the worst economic environments since the Great Depression. The case describes the current economic environment and then examines the history of the founders and the company. Google’s stages of growth, strategies, and its keys to success are then examined. Specific attention is paid to the location of the firm in regards to Silicon Valley and Stanford University. The latter part of the case focuses on the heart of the success of Google, corporate entrepreneurship and innovation. The case describes what corporate entrepreneurship and innovation is and how it is utilized within Google. The case ends with the founders asking the reader what recommendations they would make to Google to solve their problems.
Download Free PDF View PDF
Entrepreneurship Theory & Practice
In May 2009, Sergey Brin and Larry Page, co-founders of Google, Inc., were trying to determine how they were going to navigate Google through the worst recession since the Great Depression. Their primary problem was how to maintain the company’s culture of corporate entrepreneurship and innovation in the face of stagnant profits and a host of other issues. Google sought answers on how to increase corporate entrepreneurship and innovation during the worst economic environment that the company had ever experienced.
Download Free PDF View PDF
Download Free PDF View PDF
E-cadherin, vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMPs) are important molecules involved in tumor metastasis. In this study, we examined the expressions of E-cadherin, VEGF, MMP-1, MMP-2, and microvessel density (MVD), as well as microlymphatic vessel density (MLVD) in 200 cases of gastric cancer tissues, and determined the relationship between these parameters and the clinicopathological features and patient survival. Protein expressions, MVD, and MLVD were detected by immunohistochemistry. The correlation between the expression levels of these molecules and the clinicopathological features was analyzed. Patient survival was estimated by Kaplan and Meier analysis. Compared to normal gastric mucosa, expression of E-cadherin was reduced in 78% of gastric cancer tissues and 44.6% of adjacent non-cancerous gastric tissues. VEGF was positive in 81.5% of gastric cancer tissues, 35.7% of adjacent non-cancerous gastric tissues, and 10% of normal gastric mucosa. MMP-1 was positive in 80.5% of gastric cancer tissues, 69.6% of adjacent non-cancerous gastric tissues, and 20% of normal gastric mucosa. Reduced expression of E-cadherin was closely correlated with poor tumor differentiation and a deeper tumor invasion. Increased expressions of VEGF and MMP-1 were closely linked with poor differentiation and Lauren classification. Increased expression of MMP-2 was closely correlated with more lymph node metastasis, a deeper invasion, and a larger tumor size. More MVD was observed in VEGF-positive tissues than in VEGF negative tissues. Therefore, abnormal expressions of E-cadherin, VEGF, MMP-1, and MMP-2 are widely present in gastric cancer tissues. Abnormal expressions of E-cadherin, VEGF, and MMP-2 may represent the early molecular changes in the development of gastric cancer. Positive expression of E-cadherin and negative expression of VEGF and MMP-2 are correlated with a better patient survival.
Download Free PDF View PDF